Phospholipase C signaling pathway and M channel modulation
- VernacularTitle:磷脂酶C信号通路与M通道调控
- Author:
Boyi LIU
;
Zhanfeng JIA
;
Hailin ZHANG
- Publication Type:Journal Article
- Keywords:
PLC signaling pathway;
M channel;
PIP_(2);
Ca~(2+);
PKC
- From:
Academic Journal of Second Military Medical University
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
As an outward,voltage-dependent potassium channel,M type channel is crucial in the regulation of neuronal excitability;it is modulated by a variety of factors in vivo and its dysfunction often results in neuronal system diseases.Great efforts have been made to elucidate the mechanism underlying M channel modulation since its discovery decades ago.It is generally accepted that the Phospholipase C(PLC) signaling pathway plays a significant role in the M channel modulation.This review highlights the relationship between PLC signaling pathway and M channel modulation,as well as some recent progresses in the research of this field.
