Application of gene chips in medical research
- VernacularTitle:基因芯片技术在医药研究中的应用
- Author:
Zhanjun ZHANG
;
Peng LI
;
Huilan LIU
;
Yongyan WANG
- Publication Type:Journal Article
- Keywords:
chip;
screen apparatus;
imaging apparatus
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Gene chips can detect the expression of thousands of genes simultaneously.In this article,gene chips,as a screen apparatus and an imaging apparatus,were depicted according to its main uses.As a screen apparatus,in most researches,on account of different objects,the differential genes were screened by using experimental samples or tissues/cells on different times and different dosage;as an imaging apparatus,gene expression profile was used to discriminate different physiological and pathological characters in different tissue in order to diagnose a disease,which was good for vast data towards application.For bioinformatics analysis on data,at present,some cluster analyses such as non-supervised cluster,k-means and SOM are common analytical means,which presume the function of unknown genes by assisting experimental effects of chips through different algorithms,and judge pathogenesis,diagnose and treated target of diseases.In a word,gene chips is not only a kind of simple molecular biology technology,but also brings us from the period of acquiring knowledge to the period of dealing with information,which provides necessary preparation for researches from decomposed analysis to systemic biology.
