Immunological regulation of tripeptide tyroserleutide(YSL) on mice bearing ascitic fluid-type hepatocarcinoma H_(22)
- VernacularTitle:三肽化合物酪丝亮肽(YSL)对腹水型肝癌H_(22)小鼠免疫调节作用实验研究
- Author:
Zhi YAO
- Publication Type:Journal Article
- Keywords:
tripeptide tyroserleutide(YSL);
ascitic fluid-type hepatocarcinoma H_(22) model;
survival time;
anti-tumor effect
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
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Abstract:
Aim This study aimed to observe effects of tyroserleutide(tyrosyl-seryl-leucine,YSL) on the survival time of mice transplanted with the ascitic fluid-type hepatocarcinoma H_(22),as well as the T lymphocyte transformation and killing activity of NK cell impacted by YSL on mice bearing H_(22) tumor.Methods The model of ascetic fluid-type hepatocarcinoma H_(22) was established and the survival time of mice bearing H_(22) tumor treated by YSL was observed.MTT was used to observe the effect of lymphocyte transformation and killing activity of NK cells activated by YSL in vitro.Results YSL could significantly prolong the survival time of mice bearing ascetic fluid-type hepatocarcinoma H_(22).At doses of 5 and 50 ?g?kg~(1),YSL could advance the T lymphocyte transformation.At doses of 0.5,5 and 50 ?g?kg~(-1),YSL could enhance the killing activity of NK cells on mice bearing H_(22) tumor.Conclusion YSL can significantly prolong the survival time of mice bearing fluid-type hepatocarcinoma H_(22) and promote the effect of T lymphocyte transformation and NK cell killing activity.
