Effects of naloxone on IL-1?-induced fever and the content of cAMP and HSP70 in hypothalamus in rats
- VernacularTitle:纳洛酮对IL-1?致热大鼠体温及下丘脑中cAMP和HSP70含量的影响
- Author:
Xin QIN
;
Yu CAO
;
Huiling WANG
;
Hongyan ZHAO
;
Shufen ZHAO
- Publication Type:Journal Article
- Keywords:
fever;
naloxone;
IL-1?;
cAMP;
HSP70
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the role and mechanism of opioid receptor on IL-1?-induced fever.Methods Rats were dealed with intracerebreventricular administration of naloxone and/or IL-1?.Changes in body temperature were measured.The content of cAMP and HSP70 expression in hypothalamus were detected.Results Naloxone can limit IL-1?-induced fever and decrease the content of cAMP and HSP70 expression in hypothalamus(P
