Clinical significance of the defermination of serum leptin and soluble leptin receptor levels in patients with lupus erythematosus
- VernacularTitle:红斑狼疮患者瘦素及可溶性瘦素受体检测的临床意义
- Author:
Yan WANG
;
Xiuping HAN
;
Jiuhong LI
- Publication Type:Journal Article
- Keywords:
Leptin;
Soluble leptin receptor;
Lupus erythematosus
- From:
Chinese Journal of Practical Internal Medicine
2006;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the possible association of serum leptin(Lp)and soluble leptin receptor(sLR)levels in patients with different clinical types of lupus erythematosus(LE)and the disease activity of system lupus erythematosus(SLE).Methods 39 patients with LE were randomly enrolled from Department of dermatology of Sheng Jing Hospital of China Medical University and No.1 Hospital of China Medical University from 2004 to 2005,and 31 normal controls(age-,sex-and body mass index(BMI)-matched)were enrolled in this study.Fasting blood samples were obtained,and serum Lp levels were measured by using radioimmunoassay,and sLR levels were measured by using enzyme-linked immunosorbent assay(ELISA).Results(1)The patients had significantly higher serum Lp levels,but lower sLR levels than that of the control group(P0.05).(2)Lp was in positive relation with BMI,but in negative relation with sLR.The disease activity of SLE showed positive correlation with the serum Lp levels,but negative correlation with sLR levels by Kendall's correlation analysis(P
