The effect of Guhong on the capability of brain to resist ischemia
- VernacularTitle:谷红对抵抗大鼠脑缺血能力影响的研究
- Author:
Weihai XUN
;
Liying CUI
;
Pingping ZUO
- Publication Type:Journal Article
- Keywords:
Cerebral infarction;
Guhong;
Apoptosis protein
- From:
Chinese Journal of Practical Internal Medicine
2006;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective We investigated the effect of Guhong on the capability of brain to resist ischemia.Methods MCAO model was established in SD rats.TTC staining was performed in Guhong group with intraperitoneal injection and routine MCAO model group.Infarction volume was compared.Immunochemistry was performed to observe Caspase 3 expression in peri-infarct cortice of both of the groups.Results Guhong intraperitoneal injection significantly reduced the infarction volume(P﹤0.05).Caspase 3 expression was lower in Guhong group as compared with the model group.Conclusion Guhong may strengthen the capability of brain to resist ischemia.Anti-apoptosisinduced by Guhong may be the one of the underlied mechanisms.
