Effects of GSTT on release of TNF-? and IL-1? in rats with myocardial ischemia/reperfusion injury
- VernacularTitle:蒺藜总皂苷对心肌缺血再灌注损伤炎症因子TNF-?、IL-1?释放的影响
- Author:
Huijun YIN
;
Xiangang WANG
;
Dazhuo SHI
- Publication Type:Journal Article
- Keywords:
gross saponins from Tribulus terrestris;
reperfusion injury;
tumor necrosis factor;
interleukin-1
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of GSTT on the release of inflammatory molecules such as TNF-? and IL-1? in rats after ischemia/reperfusion injury. Methods An in vivo model of myocardial ischemia 45min followed by 2h reperfusion was made by reversibly ligating coronary left descending artery. 32 Sprague Dawley (SD) rats were divided randomly to 4 groups, ie: sham-operated group, model group, large and dosage of GSTT. TNF-? and IL-1? concentrations were examined by radioimmunoassay. Results Compared with model group, large dosage of GSTT significantly decreased the contents of TNF-? and IL-1?(P
