Experimental study on the formation of intravascular microthrombosis in brain after traumatic brain injury in rat
- VernacularTitle:大鼠侧向液压脑损伤后脑血管内血栓形成的实验研究
- Author:
Jun ZHANG
;
Bainan XU
;
Chong LI
- Publication Type:Journal Article
- Keywords:
brain injuries;
intracranial thrombosis;
models, animal
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the formation of intravascular microthrombosis in the brain after traumatic brain injury in rat in order to study the potentially causal linkage between thrombosis and post-traumatic cerebral ischemia. Methods Lateral fluid percussion injury (FPI) model was reproduced in the present study to prodace acute brain injury in rats. The rats were sacrificed at 12, 24, 72 hours and 7days after traumatic brain injury. Sham-injured animals received identical craniotomy without FPI. Pathological studies were performed to study the distribution and severity of intravascular microthrombosis in the brain. The difference in the severity of intracerebral thrombosis between groups was evaluated. Results Abundant fibin thrombi were found in all injured rats as compared with the controls (P
