Effects of simulated gravity loss on nuclear factor kappa-B expression in rats′ pulmonary tissue
- VernacularTitle:模拟失重对大鼠肺组织NF-?B表达的影响
- Author:
Tianzhi LI
;
Changting LIU
;
Xianghong LI
- Publication Type:Journal Article
- Keywords:
weightlessness simulation;
lung;
NF-kappa B
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of simulated gravity loss on nuclear factor Kappa-B expression in rats′ pulmonary tissue, and to investigate the mechanism of changes in NF-?B during simulated loss of gravity. Methods Tail-suspension(TS) was used as the method to simulate the physiological effects of weightlessness. 40 Wistar male rats Wistar rats were randomly divided into 4 groups: control for 7 days (7d CON), 21d CON, TS for 7d (TS7d) and TS21d. The dynamic express of nuclear factor Kappa-B in lung tissue was respectively assessed using the immunohisochemical technique. Results Compared with control group, the expression level of NF-?B in the lung tissue of tail-suspension 7d rats was elevated significantly (P
