Comparative study of effect and adverse drug reaction in treating acute alcoholism with diazepam through different routes
- VernacularTitle:地西泮肌内和静脉给药治疗急性酒精中毒兴奋患者的疗效和不良反应比较
- Author:
Feifan LIU
;
Xiaoping LI
;
Bo CHENG
- Publication Type:Journal Article
- Keywords:
alcoholic intoxication;
diazepam;
injections, intramuscular;
injections, intravenous
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect and adverse drug reaction (ADR) of Diazepam when used to treat acute alcoholism for establishing its rational use. Methods According to the administration of the drug through different routes, 158 patients admitted from Jan. 2000 to Jan. 2006 were divided into two groups- intramuscular group (i.m., n=91) and intravenous group (i.v., n=67). There was no significant difference in age, sex, amount of liquor taken, time of seeing doctor, and drug dosage between the two groups. The effect and adverse drug reaction (ADR) of Diazepam were statistically analyzed. Results No ADR occurred in i.m. group and the effective rate was 92.31%. Although the effective rate in i.v. group was 100%, 3 patients suffered from cardiac arrest, 2 patients were found to have aspiration and apnea suddenly, and the ratio of ADR was 7.46%. Conclusion It is better to use intramuscular injection rather than intravenous injection in treating acute alcoholism with Diazepam, in order to avoid the serious medical incidents.
