Prevalence of Hypothyroidism in Patients with Chronic Kidney Disease.
- Author:
Da Hyen LEE
1
;
Young Deok JEON
;
Seung Hun LEE
;
Ga Seul MUN
;
Su Sie NA
;
Huk Hwan CHA
Author Information
1. Department of Nephrology, National Medical Center, Seoul, Korea. ydjeon62@hotmail.com
- Publication Type:Original Article
- Keywords:
Chronic renal insufficiency;
Hypothyroidism
- MeSH:
Adult;
Blood Glucose;
Cholesterol;
Dialysis;
Diet;
Fasting;
Glomerular Filtration Rate;
Health Promotion;
Humans;
Hypothyroidism;
Iodine;
Kidney;
Kidney Failure, Chronic;
Korea;
Logistic Models;
Prevalence;
Renal Dialysis;
Renal Insufficiency, Chronic;
Retrospective Studies;
Thyroid Diseases
- From:Korean Journal of Medicine
2011;81(3):334-339
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Primary thyroid disease is prevalent in chronic renal disease, especially in patients requiring chronic dialysis. However, the relationship between kidney function and the prevalence of primary thyroid disease has not been studied in Korea, a nation where the dietary iodine intake is excessive. METHODS: Retrospective data from 2201 consecutive adult patients who visited a health promotion center over the last 5 years were analyzed; specifically, 54 patients with chronic kidney disease not requiring hemodialysis and 64 adults treated with hemodialysis. The glomerular filtration rate (GFR) was estimated using the abbreviated Modification of Diet in Renal Disease equation. Multivariable logistic regression was used to evaluate the independent association between the prevalence of primary hypothyroidism and estimated GFR. RESULTS: The prevalence of overt hypothyroidism increased from 0.5% at an estimated GFR > 90 mL/min/1.73 m2 to 6.3% in end-stage renal disease requiring chronic dialysis (p < 0.001 for trend). Compared with participants with an estimated GFR > 60 mL/min/1.73 m2, those with an estimated GFR < 60 mL/min per 1.73 m2 had an increased odds of overt hypothyroidism after adjusting for age, gender, fasting blood glucose (FBS), and the total cholesterol (TC) and triglyceride (TG) concentrations. CONCLUSIONS: These findings suggest that overt primary hypothyroidism is relatively common (6.3%) among persons with chronic kidney disease requiring chronic dialysis, and it is independently associated with a progressively lower estimated GFR.
