Expression of survivin and bcl-xl in non-small cell lung cancer and their relationship
- VernacularTitle:非小细胞肺癌中survivin及bcl-xl基因蛋白的表达及其相关性研究
- Author:
Degan LU
;
Xiaoqing JI
- Publication Type:Journal Article
- Keywords:
Non-small lung cancer;
Survivin;
bcl-xl;
Immunohistochemistry
- From:
Chinese Journal of Practical Internal Medicine
2006;0(19):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of survivin and bcl-xl in non-small cell lung cancer(NSCLC)and their relationship.Methods The NSCLC tissuechips including 32 cores were constructed and expression of survivin and bcl-xl was examined by immunohistochemical technique in 30 normal bronchial epithelium and 32 primary NSCLC.Results The positive rate of survivin and bcl-xl protein in NSCLC was 71.9% and 81.3% respectively,significantly higher than that in the normal ones(P0.05).The expression of bcl-xl protein was closely related to cell differentiation(P0.05).The over-expression of survivin and bcl-xl was positively correlated(P
