Relationship between blood ox-LDL levels in coronary sinus and impaired endothelium-dependent vasodilation in patients with coronary artery disease
- VernacularTitle:冠心病患者冠脉循环ox-LDL水平与内皮依赖舒张功能关系的研究
- Author:
Hongmei DONG
;
Lan HUANG
;
Yaoming SONG
;
Aimin LI
;
Xuejun YU
;
Zhaohua GENG
;
Jun JIN
;
Jun QIN
;
Gang ZHAO
;
Xiaobo ZHOU
;
Yunhua GAO
;
Hongmei XIA
- Publication Type:Journal Article
- Keywords:
coronary disease;
oxidative low density lipoprotein;
endothelium,vascular;
vasodilation
- From:Journal of Third Military Medical University
2003;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the oxidized low-density lipoprotein(ox-LDL) in the blood from the coronary sinus and impaired endothelium-dependent vasodilation in patients with coronary artery disease(CHD).Methods Four groups of patients were subjected,including acute myocardial infarction group(AMI,n=22),unstable angina group(UA,n=29),and stable angina group(SA, n=25) and control group(n=20) who was first suspected as CHD and then verified with normal coronary angiograms.Blood form the coronary sinus was collected through cardiac cathetering and the ox-LDL level was measured by Sandwich ELISA method.Brachial arterial hyperemia-induced flow mediated dilation(FMD) and sublingual nitroglycerin(NTG) mediated vasodilation were measured by high resolution ultrasound.Results The blood level of ox-LDL in patients with CHD was markedly higher than those in control group(P
