Vitamin K in treating secondary osteoporosis to nephrotic syndrome in children
- VernacularTitle:维生素K防治儿童肾病综合征继发性骨质疏松作用的研究
- Author:
Jiaqiang QIN
- Publication Type:Journal Article
- Keywords:
osteoporosis;
nephrotic sydrome;
vitamin K;
bone mineral density;
osteocalcin
- From:Journal of Third Military Medical University
2003;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the characterization of children osteoporosis and to find an effective treatment plan.Methods The children(n=62) with osteoporosis caused by nephropathy or glucocorticoid were randomized to receive vitamin K(1 mg?kg~(-1)?d~(-1)),or vitamin D(0.03 ?g?kg~(-1)?d~(-1)),or vitamin K+vitamin D from one month after hormone therapy.The markers of bone metabolism in blood and bone density were observed before and after hormone therapy.Results After 1 month after high-dose steroid administration,the bone density decreased in all children with nephrotic osteoporosis.The indexes of the children receiving vitamin K ameliorated significantly as compared with before treatment.Osteocalcin and bone specific alkaline phosphatase in blood had a positive correlation with bone density.Conclusion Osteocalcin may be regard as a bone formation index in children just as bone specific alkaline phosphatase.Vitamin K and vitamin D are of synergistic action.Vitamin K is a safe,effective and simple drug and should be used widely.
