Effect of Liangruntongluo Recipe on MOT and CCK in rats with diabetes mellitus
- VernacularTitle:凉润通络方对糖尿病大鼠胃肠MOT、CCK的影响
- Author:
Diangui LI
;
Shiling RONG
;
Jinxia JING
;
Lin PEI
;
Jie GU
;
Gang LI
- Publication Type:Journal Article
- Keywords:
Liangruntongluo Recipe;
Diabetes mellitus;
Motilin;
Cholecystokinin
- From:
International Journal of Traditional Chinese Medicine
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of Liangruntongluo Recipe in improving gastrointestinal function on DM rats induced by STZ. Methods Forty male Wistar rats were divided into four groups randomly: group A as model control group,group B as Liangruntongluo group,group C as Cisapride group,and group D as normal control group. There are 10 rats in each group. After the establishment of DM animal model with Wistar rats,the animals were raised for 6 weeks without any hypoglycemic agents. And then medicines were intragastric administrationed for another 6 weeks. In the 12th week motile and cholecystokinin in blood and tissue were tested. Result By the time of the twelfth week,the rats with DM presented the disorder of gastrointestinal hormone. Liangruntongluo Recipe affected the excretion and releasing of hormone in blood,stomach,and duodenum. With a wide target range,effect of Liangruntongluo Recipe is superior to Cisapride. Conclusions Chinese herbal medicine Liangruntongluo recipe has the superiority in improving the obstacle of the gastrointestinal function of diabetes mellitus.
