The expression of vascular endothelial growth factor and microvessel density in patients with liver cancer
- VernacularTitle:血管内皮生长因子及微血管密度在肝癌中的表达
- Author:
Wenli ZHAO
;
Qingxu YANG
;
Tongtong WU
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Vascular endothelial growth factors;
Microvessel density
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discusse the expression and clinic opathologic significance of vascular endothelial growth factor(VEGF) and microvessel density(MVD) in primary liver cancer,an immunohistochemical staining.Methods The expressions of VEGF and Ⅷ factor were determined in 60 selected operation specimen from patients with primary liver carcinoma.Results It showed that the positive expression rate of VEGF in primary liver cancer was 63.3%,the MVD was (30.76?11.56).Among them,the MVD in positive VEGF expression was (46.37?15.85),and the MVD in negative expression was (18.97?8.68),there were great statistical difference between them(P0.05).Conclusion This study indicates that VEGF can facilitate the formation of microvessel of the tumor and has correlation with the growth,infiltration and metastasis of primary liver cancer.
