Correlation of lamotrigine concentrations between saliva and serum in children with epilepsy
- VernacularTitle:癫痫儿童拉莫三嗪唾液与血清浓度的相关性
- Author:
Shen ZHANG
;
Li WANG
;
Ying LIU
- Publication Type:Journal Article
- Keywords:
lamotrigine;
saliva;
therapeutic drug monitoring;
RP-HPLC
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the correlation of LTG concentrations between saliva and serum in children with epilepsy.METHODS:After informed consent was obtained from the parents or guardian of children,children with primary epilepsy were collected in Peking University First Hospital.When reaching the steady drug concentration,(1.0) ml blood samples were obtained by phlebotomy,and(0.5) ml saliva sample were collected at the same time.Serum and salivary LTG concentrations were determined by reversed-phase high performance liquid chromatography(RP-HPLC).Statistics software SPSS11.5 was used for data analysis.RESULTS:Linear regression analysis was made by LTG concentration (C) and the peak area ratio(Y) of LTG vs.internal standard(flurazepam),and the regression equation of serum concentration and saliva concentration were Y=(0.1824)C-(0.0080),r=(0.9998) and Y=(0.1816)C-(0.0119),r=(0.9997),respectively.We collected 39 patients and 53 serum and saliva concentrations samples,of whom,27 were male and 12 female,aged 1 to 15 years(the average was(7.86)).The correlation between LTG serum concentration(x) and saliva concentration(y) was y=(0.5607)x-(0.6074)(n=53,r=(0.9501),P
