Effects of rheum tanguticum polysaccharides on ulcerative colitis induced by TNBS in mice
- VernacularTitle:唐古特大黄多糖对小鼠溃疡性结肠炎细胞因子的影响
- Author:
Rong ZHANG
;
Zhipeng WANG
;
Li LIU
;
Qibing MEI
- Publication Type:Journal Article
- Keywords:
rheum tanguticum polysaccharides;
ulcerative colitis;
TNBS
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effects of rheum tanguticum polysaccharides(RTP) on TNBS-induced colitis in mice and its probable mechanisms.METHODS: Mice colitis model was induced by 2,4,6-trinitrobenzene sulfonic acid(TNBS).The mice were randomly divided into 5 groups,normal group,model group,RTP-100,200 and 400 group.The macroscopical and histological changes of the colon were evaluated and the cytokines IL-8,IL-10,TNF-?and IL-4 produced by splenocyts were analyzed with ELISA.RESULTS: Compared with the model group,both symptoms and the lesions of colonic mucosa of RTP-200 and 400 group were slighter on ulcerative colitis induced by TNBS in mice. Furthermore,the expressions of TNF-?and IL-8 in colon tissue of mice with TNBS-induced colitis were higher and the IL-10 and IL-4 were lower than that of normal control(P
