The research of the glucokinase target for the treatment of diabetes
- VernacularTitle:以葡萄糖激酶为靶点的抗糖尿病新药研究
- Author:
Hui HUANG
;
Zhufang SHEN
- Publication Type:Journal Article
- Keywords:
glucokinase;
agonist;
diabetes
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Glucokinase (GK) is considered to be the key regulatory enzyme in glucose metabolism, whose activity changing will lead to glucose metabolic disturbance and diabetes. Recently, people have realized that there is a good extensive perspective in diabetes research by means of glucokinase investigation. In this paper, we review the mechanism of diabetes resulting from abnormality of glucokinase activity and the status of glucokinase activators, propose the viewpoint that glucokinase is a powerful target for diabetes therapy and research, and illuminate that searching of glucokinase activators is the guidance in the future.
