Apoptosis related with extracellular adenosine triphosphate and adenosine and their purinergic receptors
- VernacularTitle:细胞外ATP和腺苷及其受体与细胞凋亡
- Author:
Mingxia WANG
;
Leiming REN
;
Hongfang WANG
- Publication Type:Journal Article
- Keywords:
adenosine triphosphate;
adenosine;
apoptosis;
purinergic receptors
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Extracellular adenosine triphosphate (ATP) and adenosine are important signaling molecules in both intracellular and extracellular microenviroments of cells. They exert cytoxic and apoptotic effects in some tissues such as tumor. The proapoptotic mechanisms of adenosine and its receptors are involved in Adenylyl cyclase(AC), cAMP, Ca 2+ , etc. Apoptosis induced by ATP is as sociated with several purinergic receptors including P2X_1, P2X_2, P2X_7, P2Y_1, P2Y_2, et al, it is also involved in FasL/FasR, T cell receptor(TCR), and gene regulations of bcl-2 and bax.
