The-514C/T polymorphism of hepatic lipase and the relation to coronary heart disease
- VernacularTitle:肝脂肪酶基因-514C/T多态性与冠心病相关性研究
- Author:
Min HU
;
Jianguo SHAO
;
Yi ZHU
;
Jinde YU
- Publication Type:Journal Article
- Keywords:
coronary heart disease;
gene;
hepatic lipase
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To elucidate the polymorphism of hepatic lipasegene gene and the relation to coronary heart disease. Methods CHD group had one hundred and fifty-six patients, and each subgroup was: myocardium infarction CHD subgroup included eighty-four patients; non-myocardium infarction subgroup included seventy-two patients; pure CHD subgroup comprised sixty-five patients and hypertension and CHD subgroup comprised ninety-one patients. Phenol-Chloroform method was used to extract DNA from human peripheral blood, and a combination of polymerasechain reaction and restriction fragment length polymorphism were used to analyze the distribution of genotypes and alleles of the polymorphism site of hepatic lipase. Results The genotype and allele distribution of HL-514C/T polymorphism were significantly different between the whole CHD group and control group(P
