Protective effects and mechanism of Rutoside on lung injury during experimental acute pancreatitis
- VernacularTitle:芸香苷对实验性急性胰腺炎肺损伤的保护作用及机制
- Author:
Zheng WU
;
Weizhong ZHAO
;
Lin WANG
;
Jianhua ZHANG
- Publication Type:Journal Article
- Keywords:
rutoside;
acute pancreatitis;
lung injury
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate effects and the mechanism of rutoside (Ru) on lung injury during experimental acute pancreatitis (AP) . Methods The model of AP was induced by retrograde injection of Sodium Taurocholate(STC)into biliopancreatic duct in rat. Ru (15,30,60 mg?kg -1 ?h -1 ) was administered by intravenous infusion for 6 hours immediately after the induction of AP. Indexes of blood gas analysis, the wet/dry lung ratio and pathological changes of lung tissue were observed and we also measured levels of TNF-?, ICAM-1and NF-?B. Result Ru(60 mg?kg -1 )increased the arterial PO_2, which decreased in AP rats. Ru (30,60 mg?kg -1 ) could decrease the wet/dry lung ratio, and improve pathological changes of lung tissue. Ru(15,30,60 mg?kg -1 ) could decrease levels of TNF-?, ICAM-1, and NF-?B. Conclusion The study indicates that Ru administered by intravenous infusion exerts certain protective effects on lung injury in experimental AP rats by decreasing levels of TNF-?, ICAM-1 and NF-?B.
