Effects of hydroxysafflor yellow A on iNOS expression in rats of focal cerebral ischemic injury
- VernacularTitle:羟基红花黄色素A对局灶性脑缺血后大鼠脑组织诱导型一氧化氮合酶的影响
- Author:
Yuchen SHENG
;
Yuye XIA
;
Yang MIN
- Publication Type:Journal Article
- Keywords:
hydroxysafflor yellow A (HYSA);
focal cerebral ischemia;
iNOS
- From:
Chinese Pharmacological Bulletin
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim This was to study the effects of hydroxysafflor yellow A(HYSA)on iNOS expression in rats following focal cerebral ischemia. Methods Rat cerebral ischemia-reperfusion injury was induced by middle cerebral artery occlusion. The expression levels of iNOS were examined using immunohistochemical method. The neurological outcome and the cerebral infarct area were evaluated. Results The expression levels of iNOS in HYSA groups were significantly lower than those in ischemic model group. Treatment with HYSA also decreased the cerebral infarct area and the neurological deficit score. Conclusion HYSA induced down regulation of iNOS expression, which may mediate the protective effect of HYSA on cerebral ischemia.
