Effect of propofol pretreatment on cytokines and protection of renal ischemia/reperfusion injury in rats
- VernacularTitle:异丙酚预处理对大鼠肾缺血再灌注细胞因子的影响及损伤的保护作用
- Author:
Su LIU
;
Zhenqiang FANG
;
Genf ZHANG
- Publication Type:Journal Article
- Keywords:
ischemia/reperfusion;
tumor necrosis factor-alpha;
interleukin-6;
interleukin-8;
propofol
- From:Journal of Third Military Medical University
2003;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of propofol on tumor necrosis factor-alpha(TNF-?),interleukin-6(IL-6),interleukin-8(IL-8)in rats following renal ischemia/reperfusion and the protection of propofol on renal ischemia-reperfusion injury.Methods Seventy-two adult SD rats were randomly divided into three groups:sham operation group,ischemia/reperfusion group(I/R group)and propofol group(n=24 in each group).All the indexes of the last two groups were detected on 1,4 and 24 h after reperfusion.Five minutes before ischemia in propofol group,propofol was infused by vein and isometric physiologic saline to the other two groups.The concentration of IL-6,IL-8,TNF-? in serum and renal tissue,BUN and SCr in serum were measured.Hematoxylin and eosin staining for the renal tissue was processed.Results The concentration of IL-6,IL-8,TNF-? in serum and TNF-? in renal tissue in propofol group within 1 h after reperfusion was significantly lower than I/R group(P
