Expression and influencing factors of CD54 in Hashimotos thyroiditis
- VernacularTitle:细胞间黏附分子-1在桥本甲状腺炎中的表达及其影响因素
- Author:
Xiaohua ZENG
;
Changan LIU
;
Jijian WANG
;
Guobing YIN
- Publication Type:Journal Article
- Keywords:
intercellular adhesion molecule;
Hashimotos thyroiditis
- From:Journal of Third Military Medical University
2003;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To dectect the expression of CD54 in thyroid tissue of Hashimotos thyroiditis patients,and expression changes of CD54 on thyroid cells interferred by different agents.Methods The thyroid tissues from 41 cases of Hashimotos thyroiditis were collected and 26 normal thyroid tissues served as normal controls.All thyroid tissues were identified by pathological examination.The positive expression rate and area of CD54 were investigated by immunohistochemical method and quantitative analysis of image analysis system in all thyroid tissues.The expression changes of CD54 in the isolated thyroid cells interferred by 100,500,1 000 pg/ml IL-1? or 10 mg/L NaI or 1 000 pg/ml IL-1? and 10 mg/L NaI for 48 h were detected by flow cytometry.Results The positive expression rate of CD54 in Hashimotos thyroiditis tissues was much more than that of control tissues(P
