Pathogenetic significance of the expression of peroxisome proliferator-activated receptor?(PPAR?) mRNA in coronary artery lesions in CHD patients
- VernacularTitle:核转录因子PPAR?在冠心病患者冠状动脉损害中的作用
- Author:
Lixia YANG
;
Yuxia YANG
;
Feng QI
- Publication Type:Journal Article
- Keywords:
peroxisome proliferator-activated receptor ?;
vascular inflammation;
coronary arteriosclerosis
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the expression of peroxisome proliferator-activated receptor? (PPAR?) mRNA and the severity of coronary lesions in coronary heart disease(CHD) patients. Methods 153 patients with CHD who had undergone coronary angiography were admitted, the expression of PPAR? mRNA in peripheral lymphocytes was assessed using RT-PCR. The severity of coronary artery lesions was analyzed, and the lesions of coronary artery were delineated. Results Compared with control, in CHD patients IRI BMI TC LDL-C were elevated and HDL-C decreased. Significant decrease in PPAR? mRNA was observed in CHD patients (0.40?0.12 vs 0.62?0.13, P
