Study about serum levels of high sensitivity C-reactive protein in subjects with varying glucose tolerances and its correlation with insulin resistance.
- VernacularTitle:不同糖耐量者血清超敏C-反应蛋白表达及与胰岛素抵抗的相关性研究
- Author:
Furong ZENG
;
Jian DU
;
Lijuan CUI
- Publication Type:Journal Article
- Keywords:
Impaired glucose regulation;
Insulin resistance;
C-reactive protein
- From:
Chinese Journal of Practical Internal Medicine
2006;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the difference of serum high sensitivity C-reactive protein(hs-CRP)concentrations in subjects with various glucose tolerances,and to analyze the correlation with insulin resistance.Methods A total of 90 subjects,who came from the Medical Examination Center of the First Hospital Affiliated to China Medical University from Oct.2004 to Apr.2005,were divided into five groups according to oral glucose tolerance test(OGTT):normal glucose tolerance(NGT)group;impaired fasting glucose(IFG)group;impaired glucose tolerance(IGT)group;IFG and IGT(IGT/IFG)group;newly diagnosed,complication-free type 2 diabetes(T2DM)group.By using the ELISA methods,the concentration of serum high sensitivity C-reactive protein(hs-CRP)was measured in these subjects,and its correlation with homeostasis model assessment insulin resistance index(HOMA-IR)was andlysed.Results The concentration of hs-CRP was significantly higher in IFG,IFG/IGT,T2DM than in NGT.The concentration of hs-CRP was positively correlated with glucose metabolism index and insulin resistance index.Conclusion Our study demonstrates that inflammation already exists not only in T2DM patients but also in subjects with IFG.Inflammation might participate in the occurance and development of T2DM.
