Penehyclidine hydrochloride mediated as antagonist of muscle relaxant in aged with myocardial ischemia
- VernacularTitle:盐酸戊乙奎醚在老年心肌缺血患者肌松拮抗中的应用
- Author:
Jian CUI
;
Guocai TAO
;
Anzhi DENG
;
Ziyang ZENG
- Publication Type:Journal Article
- Keywords:
muscle relaxant;
penehyclidine hydrochloride;
antagonist;
myocardial ischemia
- From:Journal of Third Military Medical University
2003;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the advantage and safety of penehyclidine hydrochloride as the antagonist of muscle relaxant in aged patients with myocardial ischemia. Methods Sixty cases over 60 years old with myocardial ischemia in ECG were randomized to receive 15 ?g/kg atropine+40 ?g/kg neostigmine (group A),sole 20 ?g/kg penehyclidine hydrochloride (group B),20 ?g/kg penehyclidine hydrochloride +40 ?g/kg neostigmine (group C). Vital signs of antagonism were observed before and after the changes of antagonism. Results All cases had an uneventful anesthesia and operation. After antagonists were administered,heart rate and heart rate variation index increased,respiration became shallow and faster in group A. The heart rate in group B only increased mildly and the muscle tone returned very slowly as the increasing of BIS. The signs were the most desirable such as mildly lower heart rate,the minimal heart rate variation index,faster recover of muscle tone without re-relaxation,slow and deep respiration,and slowly recovered BIS. Conclusion Penehyclidine hydrochloride combined with neostigmine is suitable to reverse the muscle relaxant in aged with myocardial ischemia.
