THE ROLE OF VITAMIN B_6 TO COGNITION AND GAIT DYSFUNCTION IN POSTNATAL RATS WITH CEREBRAL PALSY
- VernacularTitle:维生素B_6对脑瘫幼鼠认知障碍和步态异常的改善作用
- Author:
Jinyu WANG
;
Yiping HOU
;
Yanfeng SONG
;
Jianping HONG
- Publication Type:Journal Article
- Keywords:
VB6;
cerebral palsy;
cognition dysfunction;
gait dysfunction
- From:
Acta Nutrimenta Sinica
1956;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the changes of cognition and gait dysfunction in postnatal rats with cerebral palsy and the possible mechanism.Method:An improved Philips method was used and the model of cerebral palsy was induced.Fifty four Wistar rats aged 14 d with cerebral palsy were randomly divided into 3 groups,cerebral palsy control group(CM,n=18),VB6 treated group(CM+VB6,n=18)and sham surgery group(CS).Morris water maze test(MWMT)was used to detect the change of cognition func-tion including the escape latency(EL)and swimming distance(SD).Footprint pattern test(FPT)was used to detect the changes of gaits inctuding the left/right stride length(LSL,RSL),front-base width(FBW),hind-base width(HBW),distance from left/right front footprint/hind footprint overlap(DLFHFO,DRFHFO).Results:MWMT:EL and SD of CM+VB6 were shorter than CM's from D 12(P 0.05).FPT:LSL and RSL were longer from D 5,and HBW and DRFHFO were shorter from D 7compared with those in CM+VB6 and CM group(P
