Paroxysmal kinesigenic Dyskinesia:Analysis of 33 cases
- VernacularTitle:发作性运动诱发性运动障碍33例分析
- Author:
Wenan WANG
- Publication Type:Journal Article
- Keywords:
Paroxysmal kinesigenic Dyskinesia;
Diagnosis;
Treatment
- From:
Chinese Journal of Practical Internal Medicine
2006;0(18):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics of the patients with paroxysmal kinesigenic dyskinesia(PKD)and it's diagnosis.Methods 33 patients with PKD were analyzed and followed up.Results Patients with PKD were liable to attacks provoked by sudden movement,startle,stress and hyperventilation and its clinical characteristics were dystonic postures,chorea,athetosis or ballism which lasted usually 3 to 10 seconds each time but never more than five minutes and recured ranging from several dozen times per day to several times per week.Moreover,patients never lost their consciousness during the attack and restored to normality during the interval.The age of onset of the disease was 4-18 years old.Eight patients had positive EEG findings,the rest of the patients' electrophysiology and neuroimaging examination showed no abnormality.All cases responded favorably to anti-epileptic drugs,especially carbamazepine.Conclusion PKD was characterized by movement induced,transient,local or generalized involuntary movement,and belonged to channelopathy.Antiepileptic drugs,particularly carbamazepine,were effective to PKD.The precise classification of the patients with paroxysmal dyskinesias is important for therapeutic decisions.
