Experimental Study on Antibacterial Effect of Baicalin Injection in Vitro
- VernacularTitle:黄芩苷注射液体外抗菌作用实验研究
- Author:
Xiping ZHANG
;
Tianmei ZHOU
;
Xiaoqing DONG
- Publication Type:Journal Article
- Keywords:
Baicalin;
Pathogenic bacteria;
Antibacterial activity
- From:
Journal of Medical Research
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the antibacterial activity of the baicalin injection in vitro.Methods The broth doubling dilution method has been adopted.And the minimal inhibitory concentration(MIC)and minimum bactericidal concentration(MBC)of baicalin injection on 161 common pathogenic bacteria obtained from clinical practice were determined.Results The MIC range of baicalin against clinically common pathogenic bacteria is 0.1～50mg/ml and the MBC range is 0.2～50mg/ml.The MIC and MBC against staphylococci is remarkably lower than those against other bacteria,with the MIC range of 0.1～6.3mg/ml and MBC range of 0.2～12.5 respectivel.The MIC50,MIC90 are respectively 0.4mg/ml and 0.8mg/ml.Conclusions The baicalin injection possesses various levels of inhibitory effect on manifold pathogenic bacteria,especially the antibacterial effect on the staphylococci.
