Application of protein transduction in gene therapy
- VernacularTitle:蛋白转导在基因治疗中的应用
- Author:
Fu XIONG
;
Cheng ZHANG
;
Meijuan YU
- Publication Type:Journal Article
- Keywords:
protein transduction;
protein transduction domain;
gene therapy
- From:
International Journal of Biomedical Engineering
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Protein transduction is an emerging technique in biological fields in recent years. Through the medium of protein transduction domain(PTD) composed by a small number of alkaline peptides, the functional proteins linked covalently with DNA, peptides, proteins or other macromolecules can across the membranes of mammalian cells, even the blood-brain barrier and transfer unconventionally that isn't like classical pathway. The distinct property of PTD that can take along fused protein entering into cells unconventionally offers a new vehicle to gene therapy for some diseases and has dulcet applied perspective.
