Effects of puerarin on blood lipid and expression of aorta laminin B1 mRNA in streptozotocin-induced diabetic rats
- VernacularTitle:葛根素对糖尿病大鼠血脂和主动脉基膜粘连蛋白B_1 mRNA表达的影响
- Author:
Qiangxiang LI
;
Caiyun WANG
;
Yulan OU
;
Jinlian HE
;
Feiyue ZHU
;
Zhuo ZHANG
;
Huiju ZHONG
- Publication Type:Journal Article
- Keywords:
puerarin;
diabetic models;
lipid;
aorta;
laminin B1 mRNA;
gene expression
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effects of puerarin on blood lipid and expression of aorta laminin B_1 mRNA in streptozotocin-induced diabetic rats. METHODS: Diabetic nephropathy rats were induced by intraperitoneal injection of STZ, and the experimental rats were divided into normal control group, model group, and puerarin group. During and after the treatment for 12 weeks, the general state, blood suger(BS), triglyceride(TC), cholesterol, low density lipoprotein(LDL-C), high density lipoprotein(HDL-C), glycosylated hemoglobin(HbA1c) and glycosylated low density lipoprotein(G-LDL) were detected. Aorta alteration of tissue morphology was observed by H.E staining, and the expressions of laminin B1 mRNA were determined by in situ hybridization analysis. RESULTS: Diabetes mellitus and aorta lesion occurred in the two model groups. Puerarin could improve the general state, decrease the level of triglyceride(P
