Semen cuscutae flavonoids protect cells of rat seminiferous tubule from apoptosis induced by serum withdraw
- VernacularTitle:菟丝子总黄酮对大鼠睾丸曲细精管无血清培养所致细胞凋亡的保护作用
- Author:
Sheng WANG
;
Danian QIN
- Publication Type:Journal Article
- Keywords:
semen cuscutae flavonoids;
testis cell;
apoptosis;
oxidative damage;
seminiferous tubule culture
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effect of Semen Cuscutae flavonoids on oxidative damage and apoptosis of rat seminiferous tubule cells. Methods Detecting apoptosis cells was performed by TUNEL methods and oxidative damage index such as MDA, T-AOC and ROS. Results Semen Cuscutae flavonoids could inhibit testis cells oxidative damage and apoptosis, the effect is dose dependent and the most significantly in 500 mg?L -1. Conclusion Semen Cuscutae flavonoids are effective antioxidants, which can inhibit apoptosis and oxidation of testis cells.
