An experimental study of pharmacokinetics and impairment of renal function with different dosage regimens of gentamicin in rats
- VernacularTitle:庆大霉素不同给药方案的药代动力学和肾功能损害的实验研究
- Author:
Liqin ZHU
;
Jianshi LOU
;
Jianjie JIAO
;
Caili ZHANG
- Publication Type:Journal Article
- Keywords:
gentamicin;
dosage regimens;
rat;
chronopharmacokinetics;
chronotoxicology
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study effects of different dosage regimens of gentamicin(GTM) on impairment of renal functions, plasma concentrations and pharmacokinetics in rats. Method 108 rats were divided into 6 groups: control group; chronological once-daily dose groups (N100 and D100 group, in which 100 mg?kg -1 GTM were intramuscularly administrated at 01 ∶00 or 13 ∶[KG-*3]00 respectively), and chronological twice-daily different dose groups (N90+D10, N70+D30, N50+D50 group, in which 90 mg?kg -1+10 mg?kg -1, 70 mg?kg -1+30 mg?kg -1 and 50 mg?kg -1+50 mg?kg -1 GTM were given at 1:00 and 13:00 respectively). The blood urea nitrogen (BUN) and creatinine (Cr) levels were observed, the plasma concentrations of GTM at 0.25,0.5,1, 2, 5 and 8h were determined, the C-T curves were profiled and the pharmacokinetic parameters were calculated at the 1st, the 10th, and the 20th day of administrations. Results ① Impairment of renal function. At the 10th day of administration, the Cr and BUN levels of N50+D50 group were the highest. There was a significant difference when compared those of the 10th day of administration with those of the 1st day of administration and of control group at same time respectively (P
