Diagnostic values of antibody to citrullinated human fibrinogen in rheumatoid arthritis
- VernacularTitle:抗瓜氨酸化纤维蛋白原抗体的检测及其在类风湿关节炎中的临床意义
- Author:
Yi ZHAO
;
Xin TIAN
;
Zhanguo LI
- Publication Type:Journal Article
- Keywords:
Fibrinogen;
Citrulline;
Enzyme-linked immunosorbent assay;
Arthritis,rheumatoid
- From:
Journal of Peking University(Health Sciences)
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the prevalence of antibody to citrullinated human fibrinogen(ACF) in rheumatic diseases and the diagnostic values in rheumatoid arthritis.Methods: Human fibrinogen was deiminated by the peptidylarginine deiminase(PAD) in the presence of Ca~(2+) in vitro.ACF was detected by ELISA in 352 patients with rheumatic diseases(183 RA,121 SLE and 48 OA) and 108 healthy controls.The sensitivity and specificity in RA were calculated and the correlations between ACF and the clinical and laboratory parameters were analysed by SPSS statistical software.Results: Compared with SLE(25.62%),OA(18.75%) and healthy control(2.78%) respectively,the patients with RA had a significantly higher level of ACF(67.21%,P
