Clinical significance of HBV-DNA quantitation for antiviral therapy in patients with chronic hepatitis B
- VernacularTitle:HBV-DNA定量在慢性乙型肝炎抗病毒治疗中的临床意义
- Author:
Peihong QIAN
- Publication Type:Journal Article
- Keywords:
Fluorescent quantitation;
Polymerase chain reaction;
HBV-DNA;
Interferon-?-2b
- From:
Chinese Journal of Primary Medicine and Pharmacy
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significancer of HBV-DNA quantitation for antiviral therapy in patients with chronic hepatitis B.Methods 125 patients were divided into two groups:group A 75 patients whose HBV-DNA quantitation were 1.0?10~5～9.9?10~6 copies/ml and group B 50 patients whose HBV-DNA quantita- tion were more than 1.0?10~7 copies/ml.Two groups were treated with interferon for half a year.Results The therapcutic effect for patients with low level HBV-DNA copies(group A)was better than that with high level HBV- DNA copies(group B).Conclusion The rates of HBV-DNA are closely related to the effect of antiveral therapy; The dynamic detection of HBV-DNA quantitation is helpful to the diagnosis,montioring,evaluation and antiviral therapy in patients with chronic hepatitis B.
