Expression and clinical significance of E2F-3 and pRb in human prostate cancer
- VernacularTitle:E2F-3,pRb蛋白在前列腺癌中的表达及其临床意义
- Author:
Yunxiang LI
;
Xin GOU
;
Weiyang HE
;
Shiqing ZHANG
- Publication Type:Journal Article
- Keywords:
prostate carcinoma;
cell cycle regulators;
E2F-3 protein;
pRb
- From:Journal of Third Military Medical University
2003;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of E2F-3 and pRb in primary prostate cancer(PCa) and its clinical significance.Methods The expression of E2F-3 protein and pRb was detected in 49 PCa,20 benign prostatic hyperplasia(BPH),10 normal prostate tissues(NP) by EliVision~(TM) plus immunohistochemical staining.Results The positive expression rate of E2F-3 in PCa,BPH,NP was 63.27%(31/49),20%((4/20)) and 10%(1/10),respectively.The expression level of E2F-3 in PCa was significantly higher than that in BPH(P
