Effect of atrovastin and nifedipine controlled released tablet on blood pressure and vascular endothelial function
- VernacularTitle:阿托伐他汀与硝苯地平控释片的协同降压作用及对血管内皮功能的影响
- Author:
Hong XUE
;
Ye ZHANG
;
Xukai WANG
;
Chengming YANG
;
Hongyong WANG
;
Chunjiang FU
- Publication Type:Journal Article
- Keywords:
essential hypertension;
atrovastin;
nifedipine controlled released tablet;
vascular endothelial cells;
endothelin-1;
nitric oxide
- From:Journal of Third Military Medical University
2003;0(15):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects on blood pressure and vascular endothelial-1 function of combined therapy of atrovastin and nifedipine controlled released tablet in essential hypertension.Methods A randomized,double-blind,controlled trial was performed.Eighty-two patients with essential hypertension were randomly divided into two groups,receiving nifedipine controlled released tablet 30 mg once daily,or atrovastin 10 mg once daily and nifedipine controlled released tablet 30 mg once daily for 12 weeks.Another 30 subjects with normal blood pressure served as normal blood pressure control.Antihypertensive efficiency was observed during the whole study period.The concentration of plasma endothelin-1(ET-1) nitric oxide(NO) were measured before and after treatment.Results Blood pressure decreased significantly in both groups,but more significant in combined therapy group.In the combined therapy group,atrovastin resulted in a significant reduction of plasma ET-1 and a rise of nitric oxide(NO)(P
