The clinical study of low-dose facilitated PCI in acute myocardial infarction
- VernacularTitle:应用小剂量溶栓剂联合经皮冠状动脉介入治疗急性心肌梗死的临床研究
- Author:
Zhenxian YAN
;
Yujie ZHOU
;
Yingxin ZHAO
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Thrombolysis;
Percutaneous coronary intervention;
Recombination tissue plasminogen activator
- From:
Chinese Journal of Practical Internal Medicine
2006;0(16):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of facilitated PCI(low-dose rt-PA combined with percutaneous coronary intervention)in acute myocardial infarction(AMI).Methods One hundred and sixteen patients with AMI were divided into low-dose facilitated PCI group(n=69)and direct PCI group(n=47).69 patients in low-dose facilitated PCI group were treated with an intravenous drip of 50 mg rt-PA and PCI,while 47 patients in direct PCI group were treated with PCI.The rates of recanalization before and after PCI,and the left ventricular ejection fraction(LVEF)and major hemorrhage and major adverse cardiac events(MACE)in hospital were compared in two groups.Results There was no significant difference in the interval from hospitalization to the PCI between low-dose facilitated PCI group and direct PCI group.Compared with direct PCI group,the rates of recanalization and TIMI grade 3 before PCI were significantly higher in low-dose facilitated PCI group(44.7% vs 21.7%,P
