Clinical study of urinary microprotein as predictors of outcome in critically ill patients
- VernacularTitle:动态监测尿微量蛋白对危重患者预后的价值
- Author:
Min YI
;
Sui MA
- Publication Type:Journal Article
- Keywords:
Albuminuria;
Prognosis;
Retinol-binding proteins;
Multiple organ dysfunction syndrome;
Alphal-microglobulin
- From:
Chinese Journal of Nephrology
2005;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the feacibility of microalbumin(MA),alpha-1 -raicroglobulin (?1-MG) ,N-acetyl-beta-D-glucosaminidase (NAG), retinol-binding protein (RBP)as predictors of outcome in critically ill patients. Methods A prospective study was underwent in 30 critically ill patients.Urinary samples were collected at ICU admission and on the third,seventh ICU day for MA,?1-MG,NAG,RBP measurement.The severity of illness was assessed by APACHE II score calculated on the first ICU day,and the degree of organ dysfunction was assessed using SOFA score calculated on the first,third,seventh ICU day. Results MA,?1-MG,the durations of ICU stay and mechanical ventilation,APACHE II score, SOFA score were relative factors of MODS and death in ICU. There was significant association of APACHE II with MA (r=0.397),?1-MG (r=0.448), and RBP (r= 0.465), respectively. The area under ROC curve of APACHE II score,SOFA score,MA,?1-MG, RBP,NAG to predicate the death in ICU were 0.875 ( P
