Expressions of TNF-?,TGF-?_1 and leptin in liver tissues with nonalcoholic lipoid hepatitis and their significance
- VernacularTitle:非酒精性脂肪性肝炎肝组织TNF-?、TGF-?_1和Leptin的表达及意义
- Author:
Xiaohui DING
;
Jingmin ZHAO
;
Yanling SUN
- Publication Type:Journal Article
- Keywords:
nonalcoholic steatohepatitis;
cytokines;
inflammation;
fibrosis
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of pivotal cytokines such as TNF-? and TGF-?_1, and leptin in human nonalcoholic lipoid hepatitis (NALH), and to explore their potential roles in the pathogenesis of NALH. Methods Liver tissue obtained from 59 patients pathologically diagnosed as nonalcoholic lipoid hepatitis and 10 healthy adult liver tissues were examined in the present study. The respective expression of TNF-?, TGF-?_1 and Leptin was qualitatively and semi-quantitatively determined at the protein expression levels by using immunohistochemical method and image analysis. Results In NALH liver tissue the expression of TNF-? appeared mainly in inflammatory cells and lining cells of liver sinusoids in zone 3, lipogranulomas and portal tract, where obvious inflammation was found. The expression was parallel to different degrees of inflammation in NALH, significant correlation was found between degree of inflammation and fibrosis and extent of expression (P
