Correlation of HLA-DQ in Chongqing Han population to toxoplasma infection
- VernacularTitle:重庆部分汉族人群HLA-DQ与弓形虫易感性研究
- Author:
Lin OUYANG
- Publication Type:Journal Article
- Keywords:
toxoplasma infection;
susceptibility;
histocompatibility antigens
- From:Journal of Third Military Medical University
2003;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between HLA-DQ and the susceptibility to toxoplasma among Chongqing Han population.Methods Toxoplasma infected subjects were screened out by cross-sectional survey,then the control subjects were selected through pair matching at the ratio of 1∶1.Polymerase chain reaction and sequence specific primer(PCR/SSP) were used to determine the frequency distribution of HLA-DQ1 and DQ3 in the two groups.Results The gene frequency distribution of DQ3 was increased among the toxoplasma infected individuals as compared with control subjects and the odds ratio(OR) of DQ3 was 4(P0.05).Conclusion HLA-DQ3 may be associated with toxoplasma infection in Chongqing Han population.
