Role of anti-proliferation of 2-(3-carboxy-1-oxoprogy1)amino-2-deoxy-D-glucose in human esophageal cancer cells
- VernacularTitle:2-(3-羧基-1-丙酰氨基)-2-脱氧-D-葡萄糖对人食管癌细胞的抗增殖研究
- Author:
Jing WU
- Publication Type:Journal Article
- Keywords:
2-(3-carboxy-1-oxoprogy1)amino-2-deoxy-D-glucose;
Eca-109 cell;
TE-1 cell;
proliferation;
apoptosis
- From:Journal of Third Military Medical University
2003;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of 2-(3carboxy-1-oxoprogy1)amino-2-deoxy-D-glucose(COPADG) on the proliferation and cell cycle of human esophageal cancer cells Eca-109 and TE-1.Methods In vitro experiments,MTT colorimetric assay was performed to determine the growth inhibitory rates of Eca-109 and TE-1 cells treated by COPADG.Flow cytometry was applied to observe the change of cell proliferation cycle and apoptosis index.Cell morphological change was observed by transmission electron microscopy.Results COPADG inhibited effectively the growth of esophageal cancer cells Eca-109 and TE-1 in a time-and dose-dependent manner(P
