A Clinical Study on Gastric Intramucosal PCO_2 and pH During Weaning from mechanical Ventilation
- VernacularTitle:胃肠粘膜pH值监测在机械通气撤离中的临床应用
- Author:
Siquan ZHANG
- Publication Type:Journal Article
- Keywords:
Gastric tonometry;
Gastric intramucosal pH(pHi);
Gastric intramucosal PCO2(PgCO2);
Gastric intramucosal acidosis;
Acute respiratory failure
- From:
Journal of Medical Research
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the gastric intramucosal pH( pHi) and gastric intramucosal carbon dioxide tension (PgCO2) in patients, using an automated recirculating air tonometer during weaning from mechanical ventilation ,and to study the value of intramucosal PCO2 and pH measurements to predict weaning outcome from mechanical ventilation.Methods The study population included thirty -two adult critically patients who were mechanically ventilated because of acult respiratory failure and were considered ready to be weaned. Thirty-two patients were randomly assigned to synchronized intermittent mandatory ventilation combined with positive end-expiratory pressure and pressure support ventilation (SIMV+PEEP+PSV) group and continuous positive airway pressure with pressure support ventilation (CPAP+PSV)group,sixteen patients in each group . Respiratory and hemodynamic variables were measured during the weaning process. Simulaneously, the gastric intramucosal PCO2 and pH were measured. At the same time, an arterial blood sample was drawn for blood gas analysis.Results Eighteen patients were successfully weaned from mechanical ventilation and fourteen failed. The gastric intramucosal pH was initially 7.35?0.13 and decreased to 7.238?0.18 during the weaning process in patients who failed (P
