Effect of atorvastain on plasma levels of nitric oxide and alpha-granule membrane protein in patients with acute cerebral infarction
- VernacularTitle:阿托伐他汀对急性脑梗死患者血浆一氧化氮及血小板?颗粒膜蛋白水平的影响
- Author:
Xiling ZHU
;
Jinzhong CHEN
- Publication Type:Journal Article
- Keywords:
Brian infarction;
Atorvastain;
Nitric oxide;
Alpha-granule membrane protein
- From:Chinese Journal of Primary Medicine and Pharmacy
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of atorvastain on plasma levels of nitric oxide(NO) and alpha-granule membrance protein-140(GMP-140) in patients with acute cerebral infarction.Methods 94 cases with acute cerebral infarction were randomly divided into the atorvastain group(48 cases) and the control group(46 cases).Plasma NO and GMP-140 were determined by the method of nitrate reductase and enzyme-linked immunosorbent assay in atorvastain group and control group at moment of hospitalization and after four weeks.Results Plasma NO and GMP-140 of atorvastain group after treatment were statistically lower than that of controls(P0.05).Conclusion Atorvastain can reduce plasma levels of NO and GMP-140 in patients with acute cerebral infarction.It can ameliorate brain injury after ischemia and has protective effect on the ischemia cerebral tissue.
