The Effect of Combined Enteral and Parenteral Nutrition for Anastomotic Leakage after Gastric Cancer Surgery.
- Author:
Kyung Goo LEE
1
;
Hyuk Joon LEE
;
Jun Young YANG
;
Seung Young OH
;
Yun Suhk SUH
;
Seong Ho KONG
;
Han Kwang YANG
Author Information
1. Department of Surgery, Seoul National University College of Medicine, Seoul, Korea. appe98@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Gastrectomy;
Anastomotic leak;
Enteral nutrition
- MeSH:
Anastomotic Leak*;
Body Mass Index;
Body Weight;
Enteral Nutrition;
Gastrectomy;
Humans;
Nutritional Status;
Nutritional Support;
Parenteral Nutrition*;
Parenteral Nutrition, Total;
Serum Albumin;
Stomach Neoplasms*
- From:Journal of Clinical Nutrition
2014;6(3):94-100
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The effectiveness of enteral nutrition for patients with anastomotic leakage after gastric cancer surgery is controversial. The purpose of this study is to compare effectiveness between combined enteral nutrition with parenteral nutrition (EPN) and total parenteral nutrition (TPN). METHODS: Patients who underwent gastric cancer surgery for primary gastric cancer from April 2010 to August 2012 were reviewed. Clinicopathologic characteristics, complication, laboratory tests, and body weight (Bwt) were compared between EPN and PN. RESULTS: Among patients with postoperative leakage within postoperative 1 month (n=43), 13 patients were supported by EPN and 23 patients by TPN. Clinicopathologic characteristics, including preoperative Bwt, body mass index, nutritional status, other complications, and TNM stage were similar. Preoperative serum albumin and Bwt were similar between EPN and TPN. However, after 1 week of nutritional support, albumin at EPN was significantly higher than that of PN (3.52+/-0.3 and 3.25+/-0.3; P=0.010). Adjusted by preoperative Bwt, preoperative nutritional status, and difference in Bwt between preoperative and pre-nutritional support period, decrease of Bwt between pre-nutritional support and discharge was significantly less at EPN than at TPN (-4.5+/-5.4% and -6.3+/-4.1%; P=0.001). CONCLUSION: In terms of the maintenance of serum albumin and Bwt during nutritional support, EPN may be a better supportive option than TPN for patients with anastomotic leakage after gastric cancer surgery.
