Recent progress in weight reduction mechanism of inhibitor of fatty acid synthase
- VernacularTitle:脂肪酸合成酶抑制剂减肥作用机制的研究进展
- Author:
Liyan ZHAO
;
Lili WANG
;
Song LI
- Publication Type:Journal Article
- Keywords:
fatty acid synthase;
inhibitor;
C75;
weight reduction;
mechanism
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Fatty acid synthase is the key enzyme which catalyzes the de novo synthesis of long-chain fatty acids from acetyl-CoA and malonyl-CoA.Only recently has it been appreciated that C75,the inhibitor of fatty acid synthase can make mice lose weight via reducing food intake and increasing energy consumption.The present paper reviews the potential mechanism by which the inhibitor of fatty acid synthase may influence the expression of hypothalamic neuropeptides mediating the behaviour of food intake in central nervous system and decrease adipose sediment or increase energy production.
