Antithrombotic activities and mechanism of NO donating-aspirin derivative Ⅱ_6
- VernacularTitle:一氧化氮供体偶联的阿司匹林衍生物Ⅱ_6抗血栓作用及其机制研究
- Author:
Yi SUN
;
Hui JI
;
Yihua ZHANG
;
Liyuan JIANG
- Publication Type:Journal Article
- Keywords:
NO donating-aspirin derivatives;
antithrombosis;
nitric oxide releasing
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the inhibitory effect of NO donating-aspirin derivative Ⅱ_6 on thrombosis and its mechanism of nitric oxide release. Methods Inferior vena cava thrombosis and cerebral thrombosis model in rats were used to investigate the antithrombotic activities of Ⅱ_6.TXB_2 and 6-Keto-PGF_(1?)in rat serum、rat aortic strip and in ECV304 cells were determined by radioimmunosay.NO content in the serum of rats and extracellular fluid of the ECV304 cells were tested with Griess reagent.Results Ⅱ_6 inhibited the thrombosis in inferior vena cava and brain,and it reduced the concentration of TXB_2.but increased NO production.Conclusion Ⅱ_6 has an inhibitory effect on thrombosis and increases NO content in vivo and vitro.
