5-HT receptor subtype-mediated depolarization in guinea pig celiac ganglion neurons
- VernacularTitle:介导豚鼠腹腔神经节细胞5-羟色胺去极化反应的受体亚型
- Author:
Shengrong CAI
;
Zhenxin HUANG
- Publication Type:Journal Article
- Keywords:
serotonin;
receptor;
celiac ganglion;
agonist;
antagonist
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To identify the serotonin(5-HT)subtype receptor mediated 5-HT-induced depolarization in guinea pig celiac ganglion(CG) neurons.Methods Intracellular recordings were made from the isolated guinea pig CG neurons.Results Cyproheptadine(5-HT_(1/2)antagonist) and BRL 24924(5-HT_(1P) receptor antagonist) reversibly inhibited 5-HT-induced slow depolarization.Whereas,spiperone(5-HT_(1A)receptor antagonist) and mianserin(5-HT_2 receptor antagonist) could not inhibit 5-HT-induced slow depolarization.MDL 72222(5-HT_3 receptor antagonist) could not inhibit 5-HT-induced slow depolarization,but it could reversibly inhibit 5-HT-induced fast depolarization.Pressure ejection of MCPP(5-HT_(1P) receptor agonist) on 5-HT sensitive neurons could induce a slow depolarization which could be inhibited by BRL 24924.Conclusion 5-HT-induced fast and slow depolarization is mediated by 5-HT_3 and 5-HT_(1P) receptor,respectively.
